From manuscript catalogues to a handbook of Syriac literature: Modeling an infrastructure for Syriaca.org

Despite increasing interest in Syriac studies and growing digital availability of Syriac texts, there is currently no up-to-date infrastructure for discovering, identifying, classifying, and referencing works of Syriac literature. The standard reference work (Baumstark's Geschichte) is over ninety years old, and the perhaps 20,000 Syriac manuscripts extant worldwide can be accessed only through disparate catalogues and databases. The present article proposes a tentative data model for Syriaca.org's New Handbook of Syriac Literature, an open-access digital publication that will serve as both an authority file for Syriac works and a guide to accessing their manuscript representations, editions, and translations. The authors hope that by publishing a draft data model they can receive feedback and incorporate suggestions into the next stage of the project.Comment: Part of special issue: Computer-Aided Processing of Intertextuality in Ancient Languages. 15 pages, 4 figure

Modeling a Body of Literature in TEI: The New Handbook of Syriac Literature

The New Handbook of Syriac Literature (NHSL) is a born-digital TEI-encoded reference work for the study of Syriac literature. The first volume, Bibliotheca Hagiographica Syriaca Electronica, was published by Syriaca.org in 2016 using a simple TEI schema to describe a single genre (hagiography) (Saint-Laurent et al. 2016; see also Saint-Laurent 2016, Zanetti 2016). Past TEI-encoding practice has focused on describing specific manuscripts or creating editions of works. By contrast, the NHSL seeks to describe abstract or conceptual works (including unpublished ones) and to relate them to people, places, and other works, as well as to the manuscripts, editions, and translations that embody them. Two key features of this encoding model include using for description of works and fully leveraging @source for scholarly citations. In preparation for expanding the NHSL to include other genres, Syriaca.org is revising the TEI schema used for hagiographic works. Among other revisions, the new model will employ RDF classes and properties as @type and @ref values, respectively, in order to aid RDF serialization. The authors actively seek feedback, suggestions, and criticism concerning this revised schema

Syriaca.org: New Digital Tools for the Study of the Medieval Middle East

National Endowment for the Humanities, International Balzan Foundation, Mellon Foundatio

Unanticipated influence of coordination mechanisms on physician workstyles and ED operational efficiency

The coordination of activities in a work context has been examined by many disciplines and in recent years the role of information systems and other artifacts has become increasingly prominent. The emergency department (ED) of a hospital in a large US city is used to study how information systems and other coordinating mechanisms affect how physicians choose to perform their work and how such choices can impact the ED’s overall operational performance. The study used direct observation of the work performed in the ED, interviews of physicians, nurses and other ED staff members, and the analysis of historical performance data. The key findings were that the existing coordination mechanisms are a mix of fixed and mobile, computer and paper-based information systems, and other artifacts. The workstyles adopted by physicians were shaped by incidental characteristics of these coordination mechanisms. Some workstyles appear to have adverse, albeit unintended, effects on aspects of the department’s operational performance

Improved Constraints on Isotropic Shift and Anisotropies of the Speed of Light using Rotating Cryogenic Sapphire Oscillators

We demonstrate that Michelson-Morley tests, which detect direction-dependent anisotropies in the speed of light, can also be used to place limits upon isotropic deviations of the vacuum speed of light from $c$, as described by the photon sector Standard Model Extension (SME) parameter $\tilde{\kappa}_{tr}$. A shift in the speed of light that is isotropic in one inertial frame implies anisotropic shifts in others. Using observer Lorentz covariance, we derive the time-dependent variations in the relative resonance frequencies of a pair of electromagnetic resonators that would be generated by such a shift in the rest frame of the Sun. A new analysis of a recent experimental test of relativity using this result constrains $\tilde{\kappa}_{tr}$ with a precision of $7.4\times10^{-9}$. This represents the first constraint on $\tilde{\kappa}_{tr}$ by a Michelson-Morley experiment and the first analysis of a single experiment to simultaneously set limits on all nine non-birefringent terms in the photon sector of the SME

The Gamma-Ray Blazar Content of the Northern Sky

Using survey data, we have re-evaluated the correlation of flat spectrum radio sources with EGRET sources in the Northern sky. A likelihood analysis incorporating the radio and X-ray properties and the Gamma-ray source localization is used to gauge the reliability of associations and to search for counterparts of previously unidentified EGRET sources. Above |b|=10deg, where the classification is complete, we find that 70% of the Northern EGRET sources have counterparts similar to the bright EGRET blazars. For several of these we identify known blazar counterparts more likely than the earlier proposed 3EG association; for ~20 we have new identifications. Spectroscopic confirmation of these candidates is in progress and we have found flat spectrum radio quasars and BL Lac counterparts with redshifts as high as 4. We also find strong evidence for a set of 28 objects with no plausible counterpart like the known EGRET Blazars. These thus represent either a new extragalactic population or a population of Galactic objects with a large scale height. The survey has been extended into the plane, where we find several new blazar candidates; the bulk of the sources are, however, Galactic. Looking ahead to the GLAST era we predict that several of the present 3EG sources are composite and that higher resolution data will break these into multiple Blazar IDs.Comment: 13 pages, 6 figures, submitted to Ap

From manuscript catalogues to a handbook of Syriac literature: Modeling an infrastructure for Syriaca.org

Despite increasing interest in Syriac studies and growing digital availability of Syriac texts, there is currently no up-to-date infrastructure for discovering, identifying, classifying, and referencing works of Syriac literature. The standard reference work (Baumstark's Geschichte) is over ninety years old, and the perhaps 20,000 Syriac manuscripts extant worldwide can be accessed only through disparate catalogues and databases. The present article proposes a tentative data model for Syriaca.org's New Handbook of Syriac Literature, an open-access digital publication that will serve as both an authority file for Syriac works and a guide to accessing their manuscript representations, editions, and translations. The authors hope that by publishing a draft data model they can receive feedback and incorporate suggestions into the next stage of the project.National Endowment for the Humanitie

Finite size effects and error-free communication in Gaussian channels

The efficacy of a specially constructed Gallager-type error-correcting code to communication in a Gaussian channel is being examined. The construction is based on the introduction of complex matrices, used in both encoding and decoding, which comprise sub-matrices of cascading connection values. The finite size effects are estimated for comparing the results to the bounds set by Shannon. The critical noise level achieved for certain code-rates and infinitely large systems nearly saturates the bounds set by Shannon even when the connectivity used is low

Atomoxetine for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in children with ADHD and dyslexia

<p>Abstract</p> <p>Background</p> <p>The objective of this study was to assess the effects of atomoxetine on treating attention-deficit/hyperactivity disorder (ADHD), on reading performance, and on neurocognitive function in youth with ADHD and dyslexia (ADHD+D).</p> <p>Methods</p> <p>Patients with ADHD (n = 20) or ADHD+D (n = 36), aged 10-16 years, received open-label atomoxetine for 16 weeks. Data from the ADHD Rating Scale-IV (ADHDRS-IV), Kaufman Test of Educational Achievement (K-TEA), Working Memory Test Battery for Children (WMTB-C), and Life Participation Scale for ADHD-Child Version (LPS-C) were assessed.</p> <p>Results</p> <p>Atomoxetine demonstrated significant improvement for both groups on the ADHDRS-IV, LPS-C, and K-TEA reading comprehension standard and composite scores. K-TEA spelling subtest improvement was significant for the ADHD group, whereas the ADHD+D group showed significant reading decoding improvements. Substantial K-TEA reading and spelling subtest age equivalence gains (in months) were achieved for both groups. The WMTB-C central executive score change was significantly greater for the ADHD group. Conversely, the ADHD+D group showed significant phonological loop score enhancement by visit over the ADHD group. Atomoxetine was well tolerated, and commonly reported adverse events were similar to those previously reported.</p> <p>Conclusions</p> <p>Atomoxetine reduced ADHD symptoms and improved reading scores in both groups. Conversely, different patterns and magnitude of improvement in working memory component scores existed between ADHD and ADHD+D patients. Though limited by small sample size, group differences in relation to the comparable changes in improvement in ADHD symptoms could suggest that brain systems related to the therapeutic benefit of atomoxetine in reducing ADHD symptoms may be different in individuals with ADHD+D and ADHD without dyslexia.</p> <p>Trial Registration</p> <p>Clinical Trial Registry: ClinicalTrials.gov: NCT00191048</p

Rudimentary G-Quadruplex-Based Telomere Capping In Saccharomyces Cerevisiae

Telomere capping conceals chromosome ends from exonucleases and checkpoints, but the full range of capping mechanisms is not well defined. Telomeres have the potential to form G-quadruplex (G4) DNA, although evidence for telomere G4 DNA function in vivo is limited. In budding yeast, capping requires the Cdc13 protein and is lost at nonpermissive temperatures in cdc13-1 mutants. Here, we use several independent G4 DNA-stabilizing treatments to suppress cdc13-1 capping defects. These include overexpression of three different G4 DNA binding proteins, loss of the G4 DNA unwinding helicase Sgs1, or treatment with small molecule G4 DNA ligands. In vitro, we show that protein-bound G4 DNA at a 3\u27 overhang inhibits 5\u27-\u3e 3\u27 resection of a paired strand by exonuclease I. These findings demonstrate that, at least in the absence of full natural capping, G4 DNA can play a positive role at telomeres in vivo